Functional neuro-imaging and post-traumatic olfactory impairment

To evaluate via a research literature survey the anterior neurological significance of decreased olfactory functioning following traumatic brain injuries.

A computer literature review was performed to locate all functional neuro-imaging studies on patients with post-traumatic anosmia and other olfactory deficits.

A convergence of findings from nine functional neuro-imaging studies indicating evidence for reduced metabolic activity at rest or relative hypo-perfusion during olfactory activations. Hypo-activation of the prefrontal regions was apparent in all nine post-traumatic samples, with three samples yielding evidence of reduced activity in the temporal regions as well.

The practical ramifications include the reasonable hypothesis that a total anosmic head trauma patient likely has frontal lobe involvement.