Related Experiment Video
Updated: May 31, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave-assisted C-C bond forming cross-coupling reactions: an overview
Vaibhav P Mehta1, Erik V Van der Eycken
1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tamannstrasse 2, Göttingen 37077, Germany.
Microwave irradiation offers an efficient alternative to traditional heating for transition-metal-catalyzed cross-coupling reactions. This review highlights recent advancements in microwave-assisted synthesis for forming crucial carbon-carbon and carbon-heteroatom bonds.
Area of Science:
- Synthetic organic chemistry
- Catalysis
- Green chemistry
Background:
- Transition-metal-catalyzed reactions are vital for forming C-C and C-heteroatom bonds.
- Cross-coupling reactions are now standard tools in organic synthesis.
- Advances in catalysts, ligands, and mechanistic understanding have driven progress.
Purpose of the Study:
- To review recent developments in cross-coupling reactions.
- To focus on the application of microwave irradiation as an alternative heating method.
- To provide insights into microwave-assisted synthetic strategies.
Main Methods:
- Exploration of transition-metal-catalyzed cross-coupling reactions.
- Application of microwave irradiation as a heating technique.
- Review of literature on recent advancements.
Main Results:
- Microwave irradiation offers a promising alternative to conventional heating methods.
- Enhanced reaction rates and yields are often observed with microwave assistance.
- Microwave-assisted cross-coupling reactions demonstrate efficiency and versatility.
Conclusions:
- Microwave irradiation is a valuable tool for accelerating cross-coupling reactions.
- This technology contributes to more efficient and potentially greener synthetic routes.
- Further exploration of microwave-assisted organic synthesis is warranted.
More Related Videos
12:07Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Related Concept Videos
Cycloaddition Reactions: Overview
Crossed Aldol Reactions: Overview
C–C Bond Formation: Aldol Condensation Overview
¹H NMR: Long-Range Coupling
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.
Cycloaddition Reactions: MO Requirements for Thermal Activation
Thermal Sigmatropic Reactions: Overview
Sigmatropic shifts are classified based on an order term [i, j ], where i and j indicate the number of atoms across which each end of the σ bond migrates. Below are examples of a [3,3] sigmatropic shift in 1,5-hexadiene, referred to as...