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Blockade of opioid receptors with naltrexone inhibits thyrotropin increase after noise stress but does not prevent
A Armario1, O Marti, A Gavalda
1Departamento de Biología Celular y Fisiología, Facultad de Ciencias, Universidad Autónoma de Barcelona, Spain.
Brain Research Bulletin
|August 1, 1990
Summary
Naltrexone, an opioid receptor blocker, reduced basal thyrotropin and blocked noise stress-induced increases. However, it did not affect thyrotropin decreases from severe immobilization stress in rats.
Area of Science:
- Neuroendocrinology
- Stress Physiology
Background:
- Endogenous opioids modulate various physiological processes, including hormone secretion.
- The role of endogenous opioids in regulating thyrotropin (TSH) secretion under stress is not fully understood.
Purpose of the Study:
- To investigate the influence of opioid receptor blockade on thyrotropin response to acute stressors in male rats.
- To determine if endogenous opioids play a role in stress-induced changes in thyrotropin secretion.
Main Methods:
- Adult male rats were administered naltrexone, an opioid antagonist.
- Thyrotropin levels were measured after exposure to acute noise stress or immobilization stress.
Main Results:
- Naltrexone significantly reduced basal thyrotropin levels.
- Naltrexone abolished the thyrotropin increase induced by acute noise stress.
- Naltrexone did not prevent the decrease in thyrotropin caused by severe immobilization stress.
Conclusions:
- Endogenous opioids may stimulate thyrotropin secretion under mild stress conditions.
- Opioid-independent mechanisms likely regulate thyrotropin inhibition during severe stress.