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Translation

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Related Experiment Video

Updated: May 31, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Sickle cell disease.

Martin M Meremikwu1, Uduak Okomo

  • 1Department of Paediatrics, College of Medical Sciences, University of Calabar, Calabar, Nigeria.

BMJ Clinical Evidence
|July 2, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates pharmaceutical and non-pharmaceutical interventions for preventing sickle cell disease complications and treating pain. It found 38 studies on various treatments, including hydroxyurea and blood transfusions.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Last Updated: May 31, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Hematology
  • Clinical Medicine
  • Pharmacology

Background:

  • Sickle cell disease (SCD) is a genetic disorder causing chronic hemolytic anemia and acute painful crises.
  • SCD significantly increases risks of stroke, organ damage, infections, and transfusion complications.
  • Prevalence is high in sub-Saharan Africa, with 1-2% of newborns affected.

Purpose of the Study:

  • To systematically review pharmaceutical and non-pharmaceutical interventions for preventing SCD crises and acute complications.
  • To evaluate interventions for managing pain during sickle cell crises.

Main Methods:

  • Systematic review of 38 studies including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to March 2010.
  • Included safety alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Evaluated effectiveness and safety of numerous interventions.
  • Included treatments such as hydroxyurea, blood transfusion, and various analgesics.
  • GRADE methodology was used to assess evidence quality.

Conclusions:

  • Information on effectiveness and safety of interventions for SCD is presented.
  • Interventions reviewed include antibiotic prophylaxis, vaccines, hydration, and pain management strategies.
  • The review covers a broad range of treatments for sickle cell disease management.