Related Experiment Video
Updated: May 31, 2026
04:05
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Summary
This systematic review evaluates non-surgical and surgical treatments for chronic anal fissures, common causes of anal pain. It synthesizes evidence on interventions like botulinum toxin and internal anal sphincterotomy for effectiveness and safety.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Background:
- Anal fissures are a frequent cause of defecation-related anal pain.
- Low dietary fiber intake is a potential risk factor for anal fissures.
Purpose of the Study:
- To systematically review the effects of non-surgical treatments for chronic anal fissure.
- To systematically review the effects of surgical treatments for chronic anal fissure.
Main Methods:
- Systematic review of 28 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to August 2009.
- Included harms alerts from FDA and MHRA.
Main Results:
- Evaluated the quality of evidence for various interventions using GRADE methodology.
- Identified studies meeting inclusion criteria for effectiveness and safety analysis.
Conclusions:
- Presents information on the effectiveness and safety of interventions for chronic anal fissure.
- Interventions reviewed include anal advancement flap, dilation, botulinum toxin, calcium channel blockers, internal anal sphincterotomy, and nitric oxide donors.
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