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Updated: May 31, 2026
09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Basal cell carcinoma.
Anthony Ormerod1, Sanjay Rajpara, Fiona Craig
1University of Aberdeen, Aberdeen, UK.
BMJ Clinical Evidence
|July 2, 2011
Summary
This systematic review evaluates treatments for basal cell carcinoma (BCC), the most common skin cancer. It analyzes interventions for short-term and long-term recurrence, providing evidence on their effectiveness and safety.
Area of Science:
- Dermatology
- Oncology
- Evidence-Based Medicine
Background:
- Basal cell carcinoma (BCC) is the most prevalent skin cancer, primarily affecting the head and neck.
- While metastasis is rare, BCC can cause significant local tissue damage and morbidity.
- Incidence is rising, particularly in younger populations, potentially linked to increased sun exposure.
Purpose of the Study:
- To systematically review interventions for basal cell carcinoma (BCC).
- To assess treatment effects on short-term (within 1 year) and long-term (≥2 years) recurrence.
- To evaluate the safety and effectiveness of various BCC treatment modalities.
Main Methods:
- Systematic review of 16 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to December 2009.
- Included harms alerts from regulatory agencies like the FDA and MHRA.
Main Results:
- Identified 16 studies meeting inclusion criteria.
- Performed GRADE evaluation to assess the quality of evidence for interventions.
- Included data on cryotherapy, curettage/electrodesiccation, fluorouracil, imiquimod, photodynamic therapy, and surgery.
Conclusions:
- Presents information on the effectiveness and safety of multiple BCC interventions.
- Covers cryotherapy/cryosurgery, curettage and cautery/electrodesiccation, fluorouracil, imiquimod 5% cream, photodynamic therapy, and surgery.
- Provides a comprehensive overview for clinicians managing basal cell carcinoma.
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