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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Chlamydia (uncomplicated, genital).

Paddy Horner1

  • 1Department of Social Medicine, University of Bristol, Bristol, UK.

BMJ Clinical Evidence
|July 2, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates antibiotic treatments for genital chlamydia, a common bacterial sexually transmitted infection (STI). It assesses the effectiveness and safety of various antibiotics for men, non-pregnant women, and pregnant women with uncomplicated infections.

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Area of Science:

  • Infectious Diseases
  • Public Health
  • Pharmacology

Background:

  • Genital chlamydia is the most frequently reported bacterial sexually transmitted infection (STI) in developed nations.
  • Women aged 16–19 years represent the most commonly affected demographic for genital chlamydia infections.

Purpose of the Study:

  • To systematically review the effects of antibiotic treatments for uncomplicated genital chlamydial infections in men and women (both pregnant and non-pregnant).
  • To evaluate the safety and effectiveness of various antibiotic interventions for genital chlamydia.

Main Methods:

  • A systematic review was conducted, searching major databases including Medline, Embase, and The Cochrane Library up to September 2009.
  • Included studies comprised 24 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Harms alerts from regulatory agencies like the US FDA and UK MHRA were also incorporated.

Main Results:

  • The review identified 24 relevant studies meeting inclusion criteria.
  • A GRADE evaluation was performed to assess the quality of evidence for the interventions studied.

Conclusions:

  • The systematic review provides comprehensive information on the effectiveness and safety of numerous antibiotics.
  • Interventions evaluated include amoxicillin, doxycycline, azithromycin, erythromycin, and tetracycline, among others.