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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Irritable bowel syndrome.

Alexander Charles Ford1, Per Olav Vandvik

  • 1Department of Academic Medicine, St. James's University Hospital, Leeds, UK.

BMJ Clinical Evidence
|July 2, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for irritable bowel syndrome (IBS), evaluating medications like 5HT3 antagonists and antidepressants, alongside therapies such as cognitive behavioral therapy (CBT) and hypnotherapy for IBS symptom management.

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Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Evidence-Based Practice

Background:

  • Irritable bowel syndrome (IBS) affects 5-20% of the population, linked to gut motility, visceral sensitivity, and psychosocial factors.
  • IBS patients often experience comorbid physical and psychiatric conditions, increasing their risk for unnecessary surgeries.
  • Understanding IBS prevalence and associated factors is crucial for effective patient management.

Purpose of the Study:

  • To systematically review and evaluate the effectiveness and safety of various interventions for irritable bowel syndrome (IBS).
  • To synthesize evidence from systematic reviews, RCTs, and observational studies on IBS treatments.
  • To provide clinicians with a comprehensive overview of available IBS therapies.

Main Methods:

  • Conducted a systematic literature review up to July 2009, searching major databases (Medline, Embase, Cochrane Library).
  • Included harms alerts from regulatory agencies (FDA, MHRA).
  • Performed a GRADE evaluation to assess the quality of evidence for interventions.

Main Results:

  • Identified 18 systematic reviews, RCTs, or observational studies meeting inclusion criteria for IBS treatments.
  • Evaluated a range of interventions including pharmacological and non-pharmacological options.
  • Assessed the quality of evidence for each intervention using the GRADE system.

Conclusions:

  • The review presents data on the effectiveness and safety of 5HT3 receptor antagonists, 5HT4 receptor agonists, antidepressants (TCAs, SSRIs), antispasmodics (including peppermint oil), CBT, hypnotherapy, fiber supplementation, and loperamide for IBS.
  • Provides a summary of evidence for various IBS treatment modalities.
  • Highlights the need for continued research and evidence-based selection of IBS therapies.