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Immunogenicity of conjugate meningococcus C vaccine in pediatric solid organ transplant recipients

Manuela Zlamy1, Johannes Elias, Ulrich Vogel

  • 1Department of Pediatrics, Pediatrics I, Medical University Innsbruck, Innsbruck, Austria.

Vaccine
|July 2, 2011
PubMed

Insights

A single Meningococcus C vaccine dose showed immunogenicity in pediatric transplant patients, with all maintaining protective antibody titers despite waning levels over six months. Booster doses may be considered for those with significantly decreasing titers.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatric Medicine

Background:

  • Solid organ transplant (SOT) patients often have altered immune responses.
  • Assessing vaccine immunogenicity is crucial for protecting immunocompromised populations.

Purpose of the Study:

  • To evaluate the immunogenicity of a single dose of conjugate Meningococcus C (Men C) vaccine.
  • To analyze serum bactericidal antibody (SBA) titers in pediatric SOT patients post-vaccination.

Main Methods:

  • Analysis of serum bactericidal antibody (SBA) titers.
  • Monitoring SBA titers at intervals after vaccination in 10 pediatric SOT patients.

Main Results:

  • All pediatric SOT patients showed increased SBA titers after vaccination.
  • Four patients exhibited a delayed immune response at one month.
  • SBA titers significantly decreased after six months, yet all patients maintained protective levels (≥1:8).

Conclusions:

  • A single dose of the conjugate Meningococcus C vaccine elicits a protective immune response in pediatric SOT patients.
  • Waning antibody titers were observed, suggesting the need for monitoring.
  • Booster doses may be considered for SOT patients with rapidly decreasing SBA titers.

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