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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Nitric oxide metabolism in asthma pathophysiology
Sudakshina Ghosh1, Serpil C Erzurum
1Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. ghoshs@ccf.org
Biochimica Et Biophysica Acta
|July 2, 2011
Summary
Asthma involves increased nitric oxide (NO) production, leading to harmful reactive nitrogen species (RNS) and reduced bronchodilation. This impacts chronic inflammation and airway reactivity in asthma patients.
Area of Science:
- Biochemistry
- Immunology
- Respiratory Medicine
Background:
- Asthma is a chronic inflammatory airway disease characterized by bronchoconstriction and hyper-reactivity.
- Recent research links asthma to elevated nitric oxide (NO) synthesis.
Purpose of the Study:
- To review the role of nitric oxide (NO) metabolites in asthma.
- To discuss their impact on chronic inflammation and airway reactivity.
Main Methods:
- Review of existing literature on asthma, nitric oxide (NO), and related metabolites.
- Analysis of data from chemistry, molecular biology, and cell biology studies in animal models and humans.
Main Results:
- Increased NO in asthmatic airways leads to reactive nitrogen species (RNS) formation.
- RNS cause protein oxidation and nitration, impairing biological functions.
- Beneficial S-nitrosothiols (RSNO), mediating bronchodilation, are decreased due to enhanced catabolism.
Conclusions:
- Metabolic products of NO are critical in asthma's chronic inflammation and airway reactivity.
- The balance of NO metabolites significantly influences asthma pathogenesis.
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