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Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...

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Related Experiment Video

Updated: May 31, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
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Published on: January 20, 2022

Computed tomography detects tissue formation in a stented engineered heart valve.

Linda M de Heer1, Ricardo P J Budde, Evert-Jan P A Vonken

  • 1Department of Cardio-Thoracic Surgery, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. l.m.deheer-2@umcutrecht.nl

The Annals of Thoracic Surgery
|July 2, 2011
PubMed
Summary

Tissue-engineered heart valves (TEHV) show promise, with scaffolds degrading and new tissue forming after 4 weeks. Computed tomography is highlighted as a key imaging technique for monitoring TEHV development in vivo.

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Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
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Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Engineering

Background:

  • Conventional heart valve prostheses have limitations.
  • Tissue-engineered heart valves (TEHV) offer a potential alternative.
  • Fabrication involves creating a stented tri-leaflet valve construct.

Purpose of the Study:

  • To evaluate the in vivo tissue formation of TEHV.
  • To assess the efficacy of different imaging modalities for TEHV monitoring.
  • To determine the suitability of computed tomography for follow-up.

Main Methods:

  • Fabrication of a stented tri-leaflet TEHV.
  • Implantation of the TEHV into the pulmonary position in a sheep model.
  • In vivo follow-up using computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography.

Main Results:

  • Scaffold degradation and new tissue formation observed by 4 weeks post-implantation.
  • Macroscopic inspection revealed small areas lacking tissue formation.
  • These areas were only discernible through computed tomographic imaging.

Conclusions:

  • TEHV demonstrate successful scaffold degradation and tissue regeneration within 4 weeks.
  • Computed tomography is a valuable tool for in vivo assessment of TEHV tissue formation.
  • CT imaging provides superior visualization of subtle tissue integration compared to MRI and echocardiography.