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Pathobiochemistry of CO poisoning
1Department of Biochemistry, Duke University Medical Center, Durham, NC.
FEBS Letters
|October 15, 1990
Abstract:
A hypothesis for the pathobiochemical mechanism of CO poisoning, amenable to in vivo testing with optical reflectance spectrophotometry, is presented. It differs from the classical formulation in which loss of cytochrome c oxidase function is attributed entirely to O2 depletion, by including ligation and oxygenation of CO as essential components of the inhibitory process.