Related Experiment Video
Updated: May 31, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Hyalinizing trabecular tumor of the thyroid: a case report
P Caraci1, A Fulcheri, C Ondolo
1Section of Internal Medicine, San Luigi Hospital, regione Gonzole 10, Orbassano (Torino) 10043, Italy.
Head and Neck Pathology
|July 2, 2011
Summary
Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm. Management should be conservative, focusing on surgical options and annual follow-up due to its generally benign nature.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm of follicular origin.
- First described by Carney in 1987, HTT exhibits unique nuclear, architectural, histochemical, and immunohistochemical characteristics.
Observation:
- A case of HTT in a 69-year-old woman with multinodular goiter is presented.
- Nonspecific clinical and ultrasonographic features led to an indeterminate fine needle aspiration biopsy (FNAB) diagnosis (THY-3).
- Histologic diagnosis of HTT was confirmed post-total thyroidectomy.
Findings:
- The study discusses the clinical and diagnostic approach to HTT, emphasizing the role of FNAB.
- Pathologic features and differential diagnoses of HTT are reviewed.
- Total thyroidectomy or hemithyroidectomy are considered adequate treatments; radioiodine ablation is not standard.
Implications:
- HTT is generally considered a benign neoplasm or one with extremely low malignant potential.
- Conservative management, including precautionary annual follow-up, is recommended after diagnosis.
- This approach aims to exclude the rare possibility of recurrence.
Related Concept Videos
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:23The Thyroid Gland
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
01:27Goiter
Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...