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Updated: May 31, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Melanoma: a new therapeutic era]
G Berthod1, K Homicsko, H Bouchaab
1Centre pluridisciplinaire d'oncologie, CHUV, Lausanne. gregoire.berthod@chuv.ch
Revue Medicale Suisse
|July 5, 2011
Summary
Melanoma incidence is rapidly increasing, particularly in younger adults. This review covers new targeted therapies and immunotherapies like tyrosine kinase inhibitors (TKI) and CTLA-4 blockade for advanced melanoma.
Area of Science:
- Oncology
- Immunology
- Dermatology
Context:
- Melanoma exhibits the fastest rising incidence in Switzerland.
- A significant portion (30%) of melanoma cases occur before age 50.
- Metastatic melanoma has a poor prognosis with current therapies, showing a median survival of approximately 8 months.
Purpose:
- To review recent advancements in melanoma treatment.
- To discuss the efficacy of novel therapeutic strategies.
- To highlight progress in understanding melanoma biology and immunity.
Summary:
- This review examines targeted therapies, specifically tyrosine kinase inhibitors (TKI).
- It also covers immunotherapies, including monoclonal antibodies targeting the CTLA-4 receptor on lymphocytes.
- These therapies represent promising new avenues for managing advanced melanoma.
Impact:
- Novel therapies offer improved outcomes for melanoma patients.
- Advancements in understanding cellular biology and immunity are driving treatment innovation.
- This review provides insights into the latest developments in melanoma management.
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