Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Dominant Mutation in G<sub>α</sub>s-Protein Increases Hair Pigmentation.

Pigment cell & melanoma research·2025

Same author

Healthy cats tolerate long-term daily feeding of Cannabidiol.

Frontiers in veterinary science·2024

Same author

Daily dosing of cannabidiol (CBD) demonstrates a positive effect on measures of stress in dogs during repeated exposure to car travel.

Journal of animal science·2024

Same author

Identifying candidate genes underlying isolated congenital anosmia.

Clinical genetics·2023

Same author

The MARS PETCARE BIOBANK protocol: establishing a longitudinal study of health and disease in dogs and cats.

BMC veterinary research·2023

Same author

Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes.

Brain : a journal of neurology·2023

Same journal

Defined bacterial consortium highlights the impact of intestinal bacteria on DNA methylation and tumorigenesis.

Genome biology·2026

Same journal

Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana.

Genome biology·2026

Same journal

UK Biobank whole-genome sequencing reveals robust contributions of rare variants to complex-trait heritability.

Genome biology·2026

Same journal

A one-week automated genome-wide optical pooled screen using OttoSeq.

Genome biology·2026

Same journal

Integrated lipidomic and transcriptomic profiling of the host response in human malaria.

Genome biology·2026

Same journal

Centromeric satellite expansion drives genome evolution in the snowy owl.

Genome biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

The mouse genetics toolkit: revealing function and mechanism.

Louise van der Weyden¹, Jacqueline K White, David J Adams

¹Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

|July 5, 2011

Summary

This summary is machine-generated.

Large-scale projects offer global access to mouse genetic resources for discovering disease genes and manipulating their function. These valuable tools accelerate research into complex genetic disorders.

More Related Videos

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Related Experiment Videos

Last Updated: May 31, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Area of Science:

Genetics
Genomics
Molecular Biology

Background:

Mouse models are crucial for understanding human diseases.
Genetic manipulation in mice is essential for functional genomics.
Access to diverse genetic resources accelerates discovery.

Purpose of the Study:

To highlight the importance of large-scale mouse genetic projects.
To emphasize the role of these resources in disease gene discovery.
To showcase the utility of mouse genetic manipulation.

Main Methods:

Leveraging large-scale genomic databases.
Utilizing advanced genetic engineering techniques in mice.
Global data sharing initiatives for mouse genetic information.

Main Results:

Rapid global availability of extensive mouse genetic data.
Facilitation of efficient disease gene identification.
Enhanced capabilities for functional analysis of genes.

Conclusions:

Large-scale mouse genetic projects are transforming biomedical research.
These resources are indispensable for advancing our understanding of genetics and disease.
Global collaboration in genetic resource development is key to future discoveries.