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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Published on: August 5, 2014

Basal functional connectivity within the anterior temporal network is associated with performance on declarative

Natalina Gour¹, Jean-Philippe Ranjeva, Mathieu Ceccaldi

¹Laboratoire Epilepsies et Cognition, INSERM U751, Marseille, France; Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Marseille, France. natalina.gour@ap-hm.fr

|July 5, 2011

Summary

Increased connectivity in the anterior temporal network (ATN) at rest is linked to better object-based memory performance in individuals with memory complaints and cognitive decline. This suggests compensatory mechanisms in early Alzheimer's disease and mild cognitive impairment.

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Area of Science:

Neuroscience
Cognitive Neurology

Background:

Spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in resting-state functional magnetic resonance imaging (fMRI) reveal coherent activity in functionally relevant brain networks.
Antero-mesial temporal structures are crucial for declarative memory and are affected early in Alzheimer's disease (AD).

Purpose of the Study:

To investigate the functional impact of basal connectivity within the anterior temporal network (ATN) on declarative memory.
To compare resting-state functional connectivity of the ATN in healthy controls, individuals with memory complaints, amnestic Mild Cognitive Impairment (aMCI), and mild AD.

Main Methods:

Resting-state fMRI was used with Independent Component Analysis to identify the ATN, including the perirhinal cortex, entorhinal cortex, hippocampal head, amygdala, and lateral temporal cortex.
Functional connectivity of the ATN, default mode network, and executive-control network was compared between patient groups and controls.
Voxel-based analysis identified specific regions of increased connectivity within the ATN.

Main Results:

Patients exhibited significantly increased functional connectivity within the ATN at rest compared to controls.
Increased connectivity was observed in the inferior and superior temporal gyrus and the uncus.
In patients, ATN connectivity positively correlated with performance on object-based anterograde and retrograde memory tasks, but not other cognitive measures.

Conclusions:

Basal connectivity within the ATN plays a functional role in object-related, context-free memory.
Elevated resting-state ATN connectivity may indicate compensatory mechanisms in response to early pathological changes in neurodegenerative diseases like AD.