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NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
Xin-hong Wan1, Shu-juan Li, Ping Cheng
1Heart Center, Beijing Chaoyang Hospital, Institute of Cardiovascular Disease, Capital University of Medical Sciences, Beijing 100020, China.
Journal of the Neurological Sciences
|July 5, 2011
Summary
A new genetic variant, rs10849373, in the NINJ2 gene is linked to increased ischemic stroke risk in Chinese Han individuals. This finding highlights NINJ2 as a potential genetic factor in stroke prevalence.
Area of Science:
- Genetics
- Neurology
- Epidemiology
Background:
- Genome-wide association studies identified single nucleotide polymorphisms (SNPs) near the NINJ2 gene associated with ischemic stroke in Caucasians.
- The NINJ2 gene is implicated as a potential candidate locus for ischemic stroke prevalence.
Purpose of the Study:
- To investigate the association between the NINJ2 gene and ischemic stroke in Chinese Han subjects.
- To identify specific genetic variants within NINJ2 that confer risk for ischemic stroke.
Main Methods:
- A hospital-based genetic association study was conducted.
- 14 tagging single nucleotide polymorphisms (tSNPs) in the NINJ2 gene were genotyped in 749 ischemic stroke cases and 924 controls.
- Statistical analyses were performed to assess the association between tSNPs and ischemic stroke, with adjustments for covariates.
Main Results:
- A significant association was found between tSNP rs10849373 in the first intron of NINJ2 and ischemic stroke (p=0.0001).
- The minor allele (A) of rs10849373 increased the risk of ischemic stroke, with an odds ratio (OR) of 1.37.
- This association remained significant after adjusting for age, gender, BMI, smoking, alcohol consumption, hypertension, and diabetes.
Conclusions:
- The study identified rs10849373 in the NINJ2 gene as a novel genetic risk factor for ischemic stroke in the Chinese Han population.
- Further genetic association and functional studies are warranted to pinpoint the causal variant in linkage disequilibrium with rs10849373.
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