Related Experiment Video
Updated: May 31, 2026
08:02
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
Published on: May 14, 2021
FIV associated neoplasms--a mini-review
Elizabeth Magden1, Sandra L Quackenbush, Sue VandeWoude
1Colorado State University, Department of Microbiology, Immunology, and Pathology, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
Veterinary Immunology and Immunopathology
|July 5, 2011
Summary
Feline immunodeficiency virus (FIV) infection in cats increases neoplasia risk, particularly B-cell lymphoma. Understanding FIV-associated cancers offers insights into lentiviral oncogenesis and human immunodeficiency virus (HIV)-related malignancies.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Retroviral infections are linked to oncogenesis and cancer formation.
- Feline immunodeficiency virus (FIV), similar to human immunodeficiency virus (HIV), is associated with an increased incidence of neoplasia in cats.
Purpose of the Study:
- To review risk factors and tumor phenotypes in FIV-infected cats.
- To compare oncogenic disease in natural versus experimental FIV infections.
- To identify similarities between FIV- and HIV-related malignancies.
Main Methods:
- Literature review of reported risk factors and tumor cell phenotypes.
- Analysis of differences between natural and experimental FIV infections.
- Comparison of FIV- and HIV-associated neoplasms.
Main Results:
- Lymphoma, predominantly B-cell origin, is the most common FIV-associated neoplasm.
- Experimentally infected cats develop neoplastic lesions earlier than naturally infected cats.
- Similarities with HIV-associated neoplasms include extranodal lymphoma and indirect oncogenesis mechanisms.
Conclusions:
- FIV-associated neoplasms, particularly B-cell lymphoma, share similarities with HIV-related malignancies.
- Further study of FIV-associated neoplasms can advance understanding of lentiviral oncogenesis.
- Insights gained benefit both human and animal health and viral-induced cancer mechanisms.
Related Concept Videos
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...