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Updated: May 31, 2026
07:50
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Thrombolysis for lower extremity bypass graft occlusion
Linn Koraen1, Monica Kuoppala, Stefan Acosta
1Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden.
Journal of Vascular Surgery
|July 5, 2011
Summary
Thrombolysis is effective for acute lower extremity bypass graft occlusion, offering good amputation-free survival rates. However, technical failure and older age increase amputation risk.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Thrombolytic Therapy
Background:
- Thrombolysis is a standard treatment for lower extremity bypass graft occlusion.
- Identifying risk factors for treatment failure and amputation is crucial.
Purpose of the Study:
- To evaluate thrombolytic therapy outcomes for acute bypass graft occlusion.
- To identify predictors of technical failure and amputation.
Main Methods:
- Retrospective review of 123 patients undergoing thrombolysis for lower limb bypass graft occlusion (2000-2008).
- Multivariate analysis to determine factors for technical failure, amputation, and mortality.
- Kaplan-Meier and log-rank tests for long-term outcomes.
Main Results:
- Technical failure occurred in 18 patients. Ischemic heart disease and older grafts were associated with thrombolysis success.
- Major amputation rates were 11% at 1 month and 25% at 1 year.
- Technical failure, older age, and synthetic grafts independently predicted major amputation.
Conclusions:
- Thrombolysis is supported for acute bypass graft occlusion due to acceptable amputation-free survival.
- Technical failure and older age are key factors for major amputation.
- Synthetic grafts showed higher technical success but increased amputation risk.
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