Related Experiment Video
Updated: May 31, 2026

07:26
Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
Mandibular second molar impaction. Part I: Genetic traits and characteristics
Yehoshua Shapira1, Tamar Finkelstein, Nir Shpack
1Department of Orthodontics, Maurice and Gabriela Goldshleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel. shapi@netvision.net.il
Summary
Mandibular second molar (MM2) impaction shows a genetic link, with higher prevalence in Chinese-Americans. Reduced mesial root length is a key factor in MM2 impaction development.
Area of Science:
- Orthodontics
- Genetics
- Oral Surgery
Background:
- Mandibular second molar (MM2) impaction requires accurate diagnosis for effective orthodontic treatment.
- Investigating genetic predispositions and distinct characteristics of MM2 impaction is crucial.
Purpose of the Study:
- To examine a potential genetic trait in MM2 impaction across two distinct populations.
- To identify and define specific characteristics associated with MM2 impaction.
Main Methods:
- Panoramic radiographs of 6,500 patients (Israeli and Chinese-American, aged 11-15) were analyzed.
- Twelve specific dental and skeletal characteristics were compared between impacted and non-impacted sides.
Main Results:
- MM2 impaction occurred in 1.8% of subjects, with higher prevalence in Chinese-Americans (2.3%) than Israelis (1.4%).
- Chinese-Americans exhibited more bilateral MM2 impactions (45%) compared to Israelis (27%).
- Unilateral impaction correlated with reduced mandibular arch dimensions, shorter MM2 mesial root length, and altered molar angulations.
Conclusions:
- Evidence suggests an autosomal genetic trait contributes to MM2 impaction, with higher penetrance in the Chinese-American population.
- Deficient mesial root length of the MM2 is identified as a primary developmental factor in impaction.
Related Concept Videos
Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Incomplete Dominance
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Mitral Valve Prolapse I: Introduction
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Pedigree Analysis
Overview