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Nonsteroidal antiinflammatory drug withdrawal in patients with stable rheumatoid arthritis
Gayle E McKellar1, Rosemary Hampson, Ann Tierney
1Department of Rheumatology, Pinderfields General Hospital, Aberford Road, Wakefield, West Yorkshire WF1 4DG, UK. gayle.mckellar@midyorks.nhs.uk
Objective:
To evaluate the effect of nonsteroidal antiinflammatory drug (NSAID) withdrawal on blood pressure (BP), 44-joint Disease Activity Score (DAS44), and functional assessments in patients with stable rheumatoid arthritis (RA).
Methods:
NSAID was withdrawn from 30 patients with stable RA (DAS44 ≤ 2.8). Other prescribed medication continued. Clinical and laboratory measures were taken at baseline, 6 weeks, and 12 weeks.
Results:
No participants required NSAID reintroduction during the study period. Significant improvement in systolic BP was noted: maximal median reduction was 7 mm Hg (baseline to 12 weeks). There was no significant deterioration in DAS44 or function. Eleven participants required additional intervention.
Conclusion:
NSAID withdrawal resulted in improvement in BP without loss of disease control.
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