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Updated: May 31, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives
Theivendren Panneer Selvam1, Palanirajan Vijayaraj Kumar, Parthasarathi Ramu
1Department of Pharmaceutical Chemistry, Srinivas College of Pharmacy, Valachil, Mangalore, 574 143 Karnataka, India. tpsphc@gmail.com
Abstract:
A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, (1)H-NMR, mass spectral and elemental analysis.
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