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Relationship between bilirubin and C-reactive protein.
Hee-Jin Hwang1, Sang-Woo Lee, Sang-Hwan Kim
1Department of Family Medicine, Myongji Hospital, Kwandong University College of Medicine, Deogyang-gu, Goyang, Gyeonggi-do, Republic of South Korea.
Clinical Chemistry and Laboratory Medicine
|July 6, 2011
Summary
Higher levels of total and direct bilirubin are associated with lower C-reactive protein (CRP) levels in healthy Korean adults. This suggests bilirubin
Area of Science:
- Biochemistry
- Cardiovascular Health
- Epidemiology
Background:
- Serum total bilirubin is inversely linked to coronary artery disease risk.
- Limited research exists on the relationship between bilirubin and C-reactive protein (CRP), a marker of vascular inflammation.
Purpose of the Study:
- To investigate the association between serum bilirubin levels (total and direct) and C-reactive protein (CRP) in apparently healthy Korean adults.
Main Methods:
- Cross-sectional study of 2307 Korean adults.
- Data collected during routine health check-ups between January 2009 and December 2009.
- Statistical analysis adjusted for various demographic, lifestyle, and clinical factors.
Main Results:
- A declining trend in CRP levels was observed as total bilirubin quartiles increased.
- Significant negative associations were found between CRP and both total and direct bilirubin after adjusting for confounders.
Conclusions:
- Elevated total and direct bilirubin levels correlate with lower serum CRP in healthy Korean adults.
- The antioxidant and anti-inflammatory properties of bilirubin metabolism are hypothesized to contribute to these findings.
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