Organization of collecting duct intercalated cells

Our understanding of the mechanisms by which the collecting duct transports HCO3 continues to evolve rapidly. The models put forth in Figure 1, though esthetically pleasing by virtue of their simplicity, will undoubtedly require modification as the above areas and others continue to be explored. It should be noted that a large percentage of the citations in this review emanate from colleagues of Dr. Donald Seldin who have been or currently are nephrologists at Southwestern Medical School in Dallas. The length of this list is testimony to the large number of investigators in the field of renal acid-base research who have been intellectually stimulated by their contact with Dr. Seldin.