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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
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Morphogenesis and bone integration of the mouse mandibular third molar.

Ivana Chlastakova1, Vlasta Lungova, Kirsty Wells

  • 1Laboratory of Animal Embryology, IAPG v.v.i., Academy of Sciences, Brno, Czech Republic.

European Journal of Oral Sciences
|July 6, 2011
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The mouse third molar (M3) develops postnatally, offering a unique model for tooth-bone integration. Researchers detailed M3 morphogenesis, revealing distinct initiation and bone encapsulation timing compared to the first molar (M1).

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Area of Science:

  • Developmental Biology
  • Craniofacial Development
  • Odontogenesis

Background:

  • The mouse third molar (M3) is a postnatal developmental model, crucial for understanding tooth-bone integration.
  • Comparing M3 and first molar (M1) development provides insights into odontogenesis variations.

Purpose of the Study:

  • To investigate the morphogenesis of the mouse M3 in relation to alveolar bone development.
  • To compare M3 development with M1, focusing on initiation, proliferation, apoptosis, and osteoclast activity.

Main Methods:

  • Morphological analysis of mandibular M3 from initiation to eruption.
  • Assessment of proliferation, apoptosis, osteoclast distribution, and gene expression.
  • Utilized three-dimensional reconstruction and explant cultures.

Main Results:

  • M3 initiation occurred perinatally, initially in soft tissue, separate from alveolar bone.
  • Bone encapsulation of the M3 bud began at postnatal day 3 (cap stage).
  • Osteoclasts appeared at postnatal day 4, increasing significantly by postnatal days 8-12 to facilitate tooth eruption by day 26.

Conclusions:

  • Mouse M3 development follows similar stages to M1 but exhibits unique timing in initiation and bone encapsulation.
  • The M3 serves as a valuable model for studying the interplay between tooth development and alveolar bone formation.