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Published on: May 17, 2024

Diabetes: treating hypertension

Sandeep Vijan1

  • 1University of Michigan, Ann Arbor, MI, USA.

BMJ Clinical Evidence
|July 6, 2011
PubMed

Insights

This systematic review examines antihypertensives and blood pressure targets for diabetes and hypertension. It found 22 studies on interventions like ACE inhibitors and diuretics, assessing their effectiveness and safety.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Hypertension affects a significant portion of adults with diabetes, increasing cardiac event risk.
  • Diabetic nephropathy exacerbates cardiac risks in hypertensive individuals with diabetes.

Purpose of the Study:

  • To evaluate the effects of antihypertensive medications in patients with diabetes and hypertension.
  • To assess the impact of different blood pressure targets in this patient population.

Main Methods:

  • A systematic review of 22 studies, including randomized controlled trials and observational studies.
  • Searches conducted in major databases (Medline, Embase, Cochrane Library) up to February 2009.
  • Inclusion of safety alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • The review identified studies on various antihypertensive drug classes.
  • Effectiveness and safety data were compiled for interventions including alpha-blockers, ARBs, ACE inhibitors, beta-blockers, CCBs, and diuretics.

Conclusions:

  • Information on the effectiveness and safety of multiple antihypertensive interventions is presented.
  • The review covers various drug classes and the impact of different blood pressure targets for managing hypertension in diabetic patients.
Abstract

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