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Updated: May 31, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Summary
Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) treatments like CPAP, oral appliances, and weight loss were reviewed for effectiveness and safety. This systematic review evaluated interventions for both severe and non-severe OSAHS.
Area of Science:
- Sleep Medicine
- Respiratory Medicine
- Clinical Evidence Synthesis
Background:
- Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a condition characterized by abnormal breathing during sleep, leading to sleep fragmentation and daytime sleepiness.
- OSAHS affects a significant portion of the population, with obesity identified as a key risk factor.
- The condition involves either central or obstructive apnoea, with obstructive apnoea resulting from upper airway obstruction.
Purpose of the Study:
- To systematically review the effects of treatments for severe obstructive sleep apnoea-hypopnoea syndrome.
- To evaluate the effects of treatments for non-severe obstructive sleep apnoea-hypopnoea syndrome.
Main Methods:
- A systematic review of medical literature was conducted, searching databases including Medline, Embase, and The Cochrane Library up to May 2008.
- Inclusion criteria encompassed systematic reviews, randomized controlled trials (RCTs), and observational studies.
- Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.
Main Results:
- The review identified 43 studies meeting the inclusion criteria, including systematic reviews, RCTs, and observational studies.
- A GRADE evaluation was performed to assess the quality of evidence for various interventions.
- Information on the effectiveness and safety of interventions was compiled.
Conclusions:
- The review presents findings on the effectiveness and safety of key interventions for OSAHS.
- Interventions evaluated include nasal continuous positive airway pressure (CPAP), strategies to enhance CPAP compliance, oral appliances, and weight loss.
- This synthesis provides evidence-based information for managing OSAHS.
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