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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: May 31, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Hodgkin's lymphoma.

Amin Rahemtulla1, Evangelos Terpos

  • 1Faculty of Medicine, Imperial College, London, UK.

BMJ Clinical Evidence
|July 6, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates chemotherapy and radiotherapy for Hodgkin's lymphoma. It found various treatment regimens, including ABVD and BEACOPP, effective for different disease stages, offering hope for improved survival rates.

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Last Updated: May 31, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Area of Science:

  • Oncology
  • Clinical Medicine
  • Evidence-Based Medicine

Background:

  • Hodgkin's lymphoma often presents with localized lumps but can involve systemic symptoms like fever and weight loss.
  • Localized disease is highly curable, with significant survival rates even for relapsed advanced stages.

Purpose of the Study:

  • To systematically review the effectiveness and safety of various chemotherapy and radiotherapy regimens for Hodgkin's lymphoma.
  • To answer specific clinical questions regarding treatment strategies for different stages and presentations of the disease.

Main Methods:

  • Conducted a systematic review of 40 studies, including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to September 2008.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified numerous treatment interventions for Hodgkin's lymphoma.
  • Performed a GRADE evaluation to assess the quality of evidence for each intervention.
  • The review encompasses a wide range of treatment combinations and strategies.

Conclusions:

  • Presents information on the effectiveness and safety of multiple interventions for Hodgkin's lymphoma.
  • Key interventions evaluated include ABVD, ABVPP, ChlVPP-EVA, COPP-ABVD, CVPP, EBVP, BEACOPP, and MOPP, often in combination with radiotherapy.
  • The findings support various treatment options for different stages of Hodgkin's lymphoma.