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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: May 31, 2026

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
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A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

Mapping the networks for pluripotency.

Kun Xue1, Jia-Hui Ng, Huck-Hui Ng

  • 1Gene Regulation Laboratory, Stem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, no. 02-01, Genome Building, 138672, Singapore.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|July 6, 2011
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells maintain pluripotency through transcription factors and signaling pathways. Research reveals interconnections between these, enabling the interconversion between different pluripotent states.

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Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

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Last Updated: May 31, 2026

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

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08:56

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Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Area of Science:

  • Stem cell biology
  • Developmental biology
  • Molecular biology

Background:

  • Embryonic stem cells (ESCs) are of great interest due to their pluripotency, the ability to differentiate into any cell type.
  • Transcription factors and signaling pathways are crucial for maintaining ESC pluripotency and the undifferentiated state.
  • Recent research highlights complex interactions between transcriptional networks and signaling pathways in regulating pluripotency.

Purpose of the Study:

  • To explore the interplay between transcription factors and signaling pathways in maintaining pluripotency.
  • To investigate the concept of distinct pluripotent states, exemplified by epiblast stem cells (EBSCs).
  • To understand the plasticity and defining characteristics of pluripotent cells.

Main Methods:

  • Analyzing the roles of transcription factors in ESC pluripotency.
  • Investigating the influence of signaling pathways on maintaining the undifferentiated state.
  • Utilizing transcription factor transduction and modulation of intracellular signaling for cell state interconversion.

Main Results:

  • Identified significant interconnections and crosstalk between transcription factors and signaling pathways governing pluripotency.
  • Demonstrated that different pluripotent states, such as those in ESCs and EBSCs, can be distinguished.
  • Showcased the ability to interconvert between pluripotent states using combined transcription factor and signaling pathway manipulation.

Conclusions:

  • The interplay between transcriptional networks and signaling pathways is fundamental to the maintenance and plasticity of pluripotent cells.
  • Understanding these regulatory mechanisms is key to dissecting the properties of different pluripotent states.
  • Methods involving transcription factor manipulation and signaling pathway modulation can effectively control pluripotent cell states.