Selective nanoprobes for 'signalling gases'

The use of arrays of chemical detectors has been realized in electronic nose applications. Recently attention has been focused on the application of e-Noses in the medical arena. These are electronic devices that typically employ non-selective gas sensitive elements for the monitoring of odours and other gaseous analytes. Currently, the lack of relative specificity to a mixture of gaseous analytes for these sensing elements makes the use of pattern recognition algorithms to process the signal and match the acquired data profile to a known pattern necessary, thus identifying the signature of the odour or gas detected. An alternative approach to chemical detection through the use of small arrays (two or three elements) of selective gas sensors made of nanostructured semiconducting films and membranes is described in this work. Sensor selectivity is defined here as higher sensitivity to a given gas or class of gases in the presence of interfering gaseous species. Transition metal oxides are key sensing elements of resistive type chemical detectors. A given oxide may be found in several polymorph phases, each having a distinct structural configuration. Gas-oxide interactions are strongly dependent on the 'structure sensitivity' of the polymorph used in sensing. This paper reviews the effect of polymorphism on the gas specificity and the importance of nanoscale processing for stabilizing the desirable oxide phases, and it introduces a gas-polymorph selection library for building the next generation of gas sensing systems with inherent selectivity to be used as non-invasive disease diagnosis tools.