Related Experiment Video

Updated: May 31, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

MicroRNAs as regulators of neural stem cell-related pathways in glioblastoma multiforme

Pilar González-Gómez1, Pilar Sánchez, Helena Mira

  • 1Unidad de Neurobiología Molecular, Área de Biología Celular y del Desarrollo, Instituto de Salud Carlos III, Ctra. Pozuelo-Majadahonda, km 2, 28220 Madrid, Spain.

Molecular Neurobiology
|July 6, 2011
PubMed

Insights

MicroRNAs regulate gene expression and are key in brain tumor development. This review focuses on microRNAs in glioblastoma stem cells, identifying potential diagnostic markers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNAs regulating gene expression.
  • They play roles in neural development, stem cell function, and cancer.
  • Glioblastoma (GBM) contains cancer stem cells (CSCs) driving tumor growth and resistance.

Purpose of the Study:

  • To review the role of miRNAs in glioblastoma (GBM) development.
  • To focus on the regulation of GBM-derived cancer stem cells (CSCs) by miRNAs.
  • To identify miRNAs as potential molecular classifiers and therapeutic targets for GBM.

Main Methods:

  • Literature review of current research on miRNAs in GBM.
  • Analysis of studies focusing on the interaction between miRNAs and GBM-CSCs.
  • Synthesis of findings to propose candidate miRNAs for classification and therapy.

Main Results:

  • miRNAs are implicated in regulating GBM-CSCs, which share properties with neural stem cells (NSCs).
  • Specific miRNAs are involved in GBM pathogenesis and CSC regulation.
  • A list of miRNAs with potential as GBM classifiers or therapeutic targets is proposed.

Conclusions:

  • miRNAs are crucial regulators in glioblastoma, particularly impacting cancer stem cells.
  • Understanding miRNA roles in GBM-CSCs offers insights into tumor biology.
  • Identified miRNAs may serve as biomarkers for GBM classification and novel therapeutic strategies.

More Related Videos

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment10:16

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment

Published on: March 28, 2022

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...