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Size-controlled nanoassemblies based on cyclodextrin-modified dextrans.

Véronique Wintgens¹, Thorbjørn Terndrup Nielsen, Kim Lambertsen Larsen

¹Systèmes Polymères Complexes, ICMPE-CNRS, 2 rue Henri Dunant, 94320 Thiais, France.

Macromolecular Bioscience

|July 6, 2011

Summary

Polymer nanoassemblies form spontaneously in water through host/guest interactions. Their size and structure are tunable by adjusting the ratio of adamantyl (Ada) and cyclodextrin (βCD) groups, allowing efficient hydrophobic compound incorporation.

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Area of Science:

Supramolecular Chemistry
Polymer Science
Nanotechnology

Background:

Host/guest interactions are crucial for self-assembly in aqueous media.
Dextran-based polymers offer versatile platforms for functionalization.
Controlling nanoassembly properties is key for targeted applications.

Purpose of the Study:

To investigate the formation and properties of polymer nanoassemblies.
To explore the influence of host/guest interactions on nanoassembly characteristics.
To assess the capacity for incorporating hydrophobic compounds into these systems.

Main Methods:

Synthesis of dextran backbones modified with adamantyl (Ada) and beta-cyclodextrin (βCD) groups.
Characterization of spontaneously formed nanoassemblies in aqueous solutions.
Analysis of nanoassembly size, structure, and properties as a function of component ratios and concentrations.

Main Results:

Nanoassembly size is dependent on the βCD:Ada ratio, total concentration, and mixture composition.
A core/shell structure is proposed, with an inner core from phase separation and an outer shell of Ada-grafted dextran.
Hydrophobic compounds like benzophenone are efficiently incorporated without altering nanoassembly properties.

Conclusions:

Host/guest interactions between Ada and βCD groups drive the formation of stable polymer nanoassemblies.
The self-assembly process is controllable, allowing for tunable nanoassembly sizes and structures.
These nanoassemblies show potential for encapsulating hydrophobic molecules in aqueous environments.