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Streptococcus pneumoniae serotype 1 causing invasive disease among children in Barcelona over a 20-year period

C Esteva1, L Selva, M F de Sevilla

  • 1Department of Microbiology, Hospital Sant Joan de Deu and University of Barcelona, Esplugues, Spain.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|July 7, 2011
PubMed

Insights

Invasive pneumococcal disease (IPD) caused by serotype 1 primarily affects children over two years old. A rising incidence suggests considering vaccination programs for this age group.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Invasive pneumococcal disease (IPD) remains a significant global health concern.
  • Serotype 1 is a notable cause of IPD, particularly in pediatric populations.
  • Understanding serotype-specific epidemiology is crucial for targeted prevention strategies.

Purpose of the Study:

  • To analyze the epidemiological trends and clinical characteristics of serotype 1 invasive pneumococcal disease in children over a 20-year period.
  • To identify the predominant clone associated with serotype 1 IPD.
  • To inform potential vaccination strategies for preventing serotype 1 IPD.

Main Methods:

  • Prospective study conducted over 20 years (1989-2008).
  • Inclusion of all culture-proven invasive pneumococcal disease cases in children admitted to a Barcelona children's hospital.
  • Analysis of isolate serotypes, clinical presentations, patient age, and molecular typing (ST306 clone).

Main Results:

  • Fifty-six isolates of serotype 1 IPD were identified.
  • The majority (85.7%) occurred in children over two years of age.
  • A significant increase in serotype 1 IPD incidence was observed between 1999-2003 and 2004-2008 (1.2 to 4.4 episodes/100,000 children).
  • Complicated and non-complicated pneumonia were the primary clinical manifestations.
  • The ST306 clone was identified in 70.4% of serotype 1 isolates.

Conclusions:

  • Serotype 1 IPD predominantly affects children older than two years.
  • The increasing frequency of serotype 1 IPD warrants attention.
  • Vaccination programs targeting children over two years should be considered to reduce the burden of serotype 1 IPD.

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