Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Anchoring-desolvating-shielding" spatially configurated Interface layer addressing the trade-off between Zn utilization, areal capacity and anti-calendar aging.

Journal of colloid and interface science·2026
Same author

USP24-dependent STAT2 stabilization mediates physiologic and pathologic bone formation.

Cell death & disease·2026
Same author

3DOM Perovskite Enabled Interfacial Microenvironment Regulation With Accelerated Complete Reconstruction to Grain-Boundary-Rich Nano-Copper for High-Current C<sub>2+</sub> Electrosynthesis.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Simultaneous detection of SARS-CoV-2 proteins and nucleic acids by coupling PNIPAM with circle-to-circle amplification.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2026
Same author

The involvement of TNFRSF25 in age-related hearing loss.

Human genetics·2026
Same author

Elbasvir triggers ferroptosis in esophageal squamous cell carcinoma through NCOA4-mediated ferritinophagy.

Medical oncology (Northwood, London, England)·2026

Related Experiment Video

Updated: May 31, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

[Research advance on universal red blood cell engineering].

Ying-Xia Tan1, Shou-Ping Ji, Feng Gong

  • 1Beijing Institute of Transfusion Medicine, Beijing 100850, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 7, 2011
PubMed
Summary

Researchers are developing universal donor red blood cells (RBCs) using antigen modification and stem cell technology. These advancements aim to overcome blood supply shortages and improve transfusion safety.

More Related Videos

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
08:53

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo

Published on: January 10, 2025

Related Experiment Videos

Last Updated: May 31, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
08:53

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo

Published on: January 10, 2025

Area of Science:

  • Transfusion Medicine
  • Biotechnology
  • Hematology

Context:

  • Universal donor red blood cells (RBCs) are crucial for transfusion medicine, especially in emergencies and for patients with rare blood types.
  • Current blood supply faces challenges including shortages and the risk of transfusion-transmitted infections.

Purpose:

  • To review recent technologies for producing universal group O donor RBCs.
  • To explore methods like enzymatic antigen modification and stem cell-derived RBCs.
  • To identify challenges and future directions in universal RBC development.

Summary:

  • Enzymatic cleavage of A and B antigens creates enzyme-converted group O (ECO) RBCs. A new glycosidase efficiently removes antigens from A1 and A2 RBCs.
  • Pegylation masks RBC antigens, creating universal, minor antigen-negative RBCs.
  • Generating universal RBCs from stem cells offers a novel blood resource, though scale-up and safety require further research.

Impact:

  • Universal RBCs could alleviate blood supply shortages and reduce the risk of transfusion reactions.
  • These technologies promise enhanced safety in clinical transfusions, addressing limitations of current blood banking.
  • Future applications include improved emergency blood transfusion protocols and management of blood-borne diseases.