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Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1
D H Hsu1, R de Waal Malefyt, D F Fiorentino
1Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
Science (New York, N.Y.)
|November 9, 1990
Abstract:
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.