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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Related Experiment Video

Updated: May 31, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Epigenetic predictor of age.

Sven Bocklandt1, Wen Lin, Mary E Sehl

  • 1Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

Plos One
|July 7, 2011
PubMed
Summary

Scientists identified 88 DNA methylation sites linked to aging. A model using two sites accurately predicts chronological age, aiding forensic science and predicting age-related disease risk.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Related Experiment Videos

Last Updated: May 31, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Area of Science:

  • Epigenetics
  • Genomics
  • Aging Research

Background:

  • Aging is a natural process involving cellular decay and changes in gene regulation.
  • DNA methylation patterns shift with age and are implicated in age-related diseases.

Purpose of the Study:

  • To identify specific DNA methylation sites correlated with chronological age.
  • To develop a predictive model for age estimation using epigenetic markers.

Main Methods:

  • Analyzed DNA methylation patterns in saliva from identical twin pairs and a general population sample.
  • Identified 88 methylation sites in or near 80 genes associated with age.
  • Validated and replicated findings in promoter regions of specific genes (EDARADD, TOM1L1, NPTX2).

Main Results:

  • Discovered 88 age-correlated cytosine methylation sites in 80 genes.
  • Identified three specific methylation sites with linear correlation to age across five decades.
  • Developed a regression model using two methylation sites, explaining 73% of age variance and predicting age with 5.2-year accuracy.

Conclusions:

  • Epigenetic markers, specifically DNA methylation, can accurately estimate chronological age.
  • This age prediction model has potential applications in forensic science and medical screening for age-related disease risk.
  • Epigenetic bio-age could inform personalized medical interventions beyond chronological age.