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Related Experiment Video

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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Striatal function in relation to negative symptoms in schizophrenia.

S Ehrlich¹, A Yendiki¹, D N Greve¹

¹MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.

Psychological Medicine

|July 8, 2011

Summary

Schizophrenia patients with negative symptoms show reduced striatal activity, not DLPFC dysfunction. This suggests striatal dysfunction is key to negative symptoms in schizophrenia.

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Area of Science:

Neuroscience
Psychiatry
Brain Imaging

Background:

Executive functioning, crucial for cognition, is often impaired in schizophrenia.
Negative symptoms in schizophrenia are linked to disruptions in the striatum and dorsolateral prefrontal cortex (DLPFC).
Previous research suggests the striatum plays a role in motivational aspects of executive function.

Purpose of the Study:

To investigate the association between negative symptoms in schizophrenia and striatal dysfunction.
To test the hypothesis that negative symptoms are primarily linked to striatal, rather than DLPFC, dysfunction.

Main Methods:

Utilized functional magnetic resonance imaging (fMRI) to measure brain activity.
Employed a region-of-interest (ROI) approach focusing on the striatum and DLPFC.
Compared 147 schizophrenia patients with 160 healthy controls, analyzing working-memory load-dependent activation and gray matter volumes.

Main Results:

No significant differences in striatal activation between patients and controls.
Schizophrenia patients showed higher right DLPFC activity compared to controls.
Negative symptoms were inversely correlated with striatal activity, but not DLPFC activity.
Patients with high negative symptoms exhibited significantly lower bilateral striatal activation than those with minimal negative symptoms.

Conclusions:

Findings support a strong association between negative symptoms and reduced striatal activity in schizophrenia.
Diminished striatal activity may serve as a potential biomarker for negative symptoms in schizophrenia.
Further research is needed to confirm the utility of striatal activity as a biomarker.