[Lipid peroxidation and antioxidant defense in patients with severe herpetic infection]

Lipid peroxidation and antioxidant defense were studied in 42 patients with severe herpetic infection. The higher plasma and red blood cell levels of intermediate (trienic conjugates) and end (Schiff's bases) lipid peroxidation products were revealed during remission and disease recurrences. At the same time, there were increases in the content of ceruloplasmin in the plasma and in that of superoxide dismutase and catalase in the red blood cells. In the patients with herpetic infection, there were different correlations between the values of lipid peroxidation and antioxidant defense, which were absent in the group of donors. There was a direct correlation between the level of oxidation of intermediate products (ketodienes) of neutral lipids in the plasma and the concentrations of ceruloplasmin and negative correlations with red blood cell superoxide dismutase in patients in remission. There were negative correlations between the red blood cell level of oxidation of intermediate phospholipid peroxidation products and the concentration of ceruloplasmin.