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Antihistamine therapy in allergic rhinitis.
Flavia C L Hoyte1, Rohit K Katial
1Division of Allergy, Asthma, and Immunology, National Jewish Health, 1400 Jackson Street, Room K624, Denver, CO 80206, USA.
Immunology and Allergy Clinics of North America
|July 9, 2011
Summary
Antihistamines are key for allergic rhinitis. Both oral and intranasal options exist, with first and second-generation types offering different side-effect profiles. Special populations need careful antihistamine selection.
Area of Science:
- Pharmacology
- Allergy and Immunology
Background:
- Antihistamines are a primary treatment for allergic rhinitis.
- Oral antihistamines are categorized into first and second generations based on properties and side effects.
Observation:
- Intranasal antihistamines represent a recent advancement, broadening treatment options.
- Different antihistamine generations possess distinct pharmacologic profiles and side-effect considerations.
Findings:
- The choice of antihistamine requires careful consideration, especially for specific patient groups.
- First-generation antihistamines may cause drowsiness, while second-generation agents generally have fewer central nervous system effects.
Implications:
- Intranasal antihistamines offer localized relief with potentially fewer systemic side effects.
- Tailoring antihistamine therapy to patient populations like children and pregnant women is crucial for safety and efficacy.
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