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Post‒cataract surgery endophthalmitis outbreak caused by multidrug-resistant Pseudomonas aeruginosa

Helena C Maltezou1, Olga Pappa, Georgios Nikolopoulos

  • 1Department for Interventions in Health Care Facilities, Hellenic Center for Diseases Control and Prevention, Athens, Greece. helen-maltezou@ath.forthnet.gr

American Journal of Infection Control
|July 9, 2011
PubMed

Insights

A 2010 outbreak of post-cataract surgery endophthalmitis involved 13 cases of multidrug-resistant Pseudomonas aeruginosa. Despite genetic similarity in eye isolates, the infection source remained unidentified after thorough investigation.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • A significant outbreak of post-cataract surgery endophthalmitis occurred in June 2010.
  • The outbreak involved 13 cases, all linked to multidrug-resistant Pseudomonas aeruginosa.

Purpose of the Study:

  • To identify the source of the multidrug-resistant Pseudomonas aeruginosa outbreak following cataract surgery.

Main Methods:

  • Pulse-field gel electrophoresis (PFGE) was used to analyze the genetic relatedness of Pseudomonas aeruginosa isolates from ocular infections.
  • Comprehensive environmental sampling and patient carriage investigations were conducted.

Main Results:

  • PFGE analysis revealed a high degree of genetic similarity (95%) among the ocular isolates, indicating a common source.
  • Despite extensive investigations, the specific environmental or carriage source of the infection was not identified.

Conclusions:

  • The study identified a common source for the multidrug-resistant Pseudomonas aeruginosa outbreak linked to cataract surgery.
  • The precise origin of the infection could not be determined, highlighting challenges in outbreak source identification.

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