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Updated: May 31, 2026
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
Published on: July 31, 2014
Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice
1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Background And Purpose:
Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke.
Methods:
We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice.
Results:
Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion.
Conclusions:
These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
