Related Experiment Video
Updated: May 31, 2026
08:47
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Development and validity of the DyNaChron questionnaire for chronic nasal dysfunction.
Sophie Kacha1, Francis Guillemin, Roger Jankowski
1Otorhinolaryngology Department, Hôpital Central, CHU de Nancy, Nancy, France.
Summary
A new questionnaire, DyNaChron, effectively measures nasal symptom impact. It assesses physical and psychosocial effects, showing good validity and reliability for research use.
Area of Science:
- Otorhinolaryngology
- Psychometrics
- Clinical Research
Background:
- Nasal symptoms significantly influence therapeutic decisions and treatment evaluation.
- Existing questionnaires lack systematic assessment of the distinct physical and psychosocial consequences of individual nasal symptoms.
Purpose of the Study:
- To develop and validate a self-reporting questionnaire (DyNaChron) to measure the physical and psychosocial repercussions of nasal symptoms.
- To assess the validity, reproducibility, and sensitivity to change of the DyNaChron questionnaire in a large patient sample.
Main Methods:
- Expert-based development and face validity testing of the DyNaChron questionnaire in French.
- Prospective multicenter study involving 759 patients for validity testing (factor analysis, ICC, Bland and Altman plots) and reproducibility.
- Sensitivity to change assessed using standardized response means.
Main Results:
- The DyNaChron questionnaire, with 78 items across six domains, was developed.
- Factor analysis confirmed a six-domain structure explaining 68.7% of variance.
- High internal consistency (Cronbach's alpha 0.93-0.96), strong reproducibility (ICC 0.8-0.92), and good sensitivity to change were demonstrated.
Conclusions:
- DyNaChron is a well-structured questionnaire with high internal consistency and validity for research.
- Further validation against other measures and development of a clinical score are warranted.
More Related Videos
Related Concept Videos
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
01:28Physical Assessment of the Respiratory Tract I: Health History
Physical assessment of the respiratory tract is critical to patient care. It allows healthcare professionals to identify and manage various respiratory conditions. The process involves a combination of subjective and objective data collection.
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and key...
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and key...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:30Assessment of Airway, Skin Color, and Use of Accessory Muscles
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
Introduction
The initial evaluation of a patient's respiratory system...