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Related Concept Videos

Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...

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Related Experiment Video

Updated: May 31, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Cyclin-dependent kinases in brain development and disease.

Susan C Su1, Li-Huei Tsai

  • 1Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, USA.

Annual Review of Cell and Developmental Biology
|July 12, 2011
PubMed
Summary

Cyclin-dependent kinase 5 (Cdk5) is crucial for nervous system function, regulating brain development and synaptic plasticity. Its dysfunction is linked to neurodegenerative diseases, highlighting its role in neurological health.

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Related Experiment Videos

Last Updated: May 31, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase vital for nervous system functions.
  • Cdk5 is activated by binding to regulatory proteins p35 and p39.
  • Cdk5 plays key roles in neuronal development, synaptic plasticity, behavior, and cognition.

Purpose of the Study:

  • To review recent literature on Cdk5's role in synaptic plasticity and homeostasis.
  • To emphasize Cdk5 kinase activity in the context of neurodegenerative conditions.

Main Methods:

  • Literature review of recent studies on Cdk5.
  • Analysis of Cdk5's function in synaptic plasticity and neurodegeneration.

Main Results:

  • Cdk5 regulates critical events in brain development, including neuronal migration and neurite outgrowth.
  • Evidence indicates Cdk5's involvement in synaptic plasticity, behavior, and cognitive functions.
  • Cdk5 dysfunction is implicated in neurological disorders such as Alzheimer's disease and ischemia.

Conclusions:

  • Cdk5 is a key regulator of neuronal function and development.
  • Dysregulation and hyperactivation of Cdk5 contribute to neurodegeneration.
  • Understanding Cdk5 activity is crucial for addressing neurological disorders.