Organization and plasticity in multisensory integration: early and late experience affects its governing principles

Neurons in the midbrain superior colliculus (SC) have the ability to integrate information from different senses to profoundly increase their sensitivity to external events. This not only enhances an organism's ability to detect and localize these events, but to program appropriate motor responses to them. The survival value of this process of multisensory integration is self-evident, and its physiological and behavioral manifestations have been studied extensively in adult and developing cats and monkeys. These studies have revealed, that contrary to expectations based on some developmental theories this process is not present in the newborn's brain. The data show that is acquired only gradually during postnatal life as a consequence of at least two factors: the maturation of cooperative interactions between association cortex and the SC, and extensive experience with cross-modal cues. Using these factors, the brain is able to craft the underlying neural circuits and the fundamental principles that govern multisensory integration so that they are adapted to the ecological circumstances in which they will be used.