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Published on: February 3, 2026
[Medical abortion from 12 through 14 weeks' gestation: a retrospective study with 126 patients]
V Lavoué1, L Vandenbroucke, A Grouin
1Service d'obstétrique, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France. vincent.lavoue@chu-rennes.fr
Summary
Medical abortion is effective between 12 and 14 weeks of gestation. However, this method requires a high rate of secondary manual uterine revision or vacuum aspiration.
Area of Science:
- Reproductive Health
- Pharmacology
Context:
- Medical abortion protocols are evolving for second-trimester gestations.
- Assessing efficacy and safety in later gestations is crucial.
Purpose:
- To evaluate a specific medical abortion protocol for gestations between 12 and 14 weeks.
- To determine the abortion rate, complication rate, and need for surgical intervention.
Summary:
- A retrospective study of 126 medical abortions (12-14 weeks) used mifepristone followed by misoprostol.
- Achieved a 98% abortion rate but a 41% rate of secondary manual uterine revision or vacuum aspiration.
- Mean expulsion time was 10.4 hours; higher parity correlated with shorter expulsion times.
Impact:
- This protocol demonstrates consistent efficacy for medical abortion up to 14 weeks.
- Highlights the significant need for surgical intervention in a substantial proportion of cases.
- Informs clinical practice regarding management of later second-trimester medical abortions.
