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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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Seedling fibroid characterization using optical coherence tomography.

Arielle S Joasil1, Daniella M Fodera2, Zhuoya Shi1

  • 1Columbia University, Department of Electrical Engineering, 500 W 120th St, New York, NY, USA.

Biomedical Optics Express
|July 16, 2026
PubMed
Summary

Optical coherence tomography (OCT) can distinguish seedling uterine fibroids from normal tissue by analyzing microstructural differences. This imaging technique shows potential for improved diagnosis and surgical planning of uterine fibroids.

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Area of Science:

  • Biomedical Engineering
  • Gynecology
  • Medical Imaging

Background:

  • Uterine fibroids are common benign tumors causing significant patient and healthcare burdens.
  • Current imaging methods fail to detect small, or seedling, fibroids, complicating diagnosis and treatment.
  • Hysterectomy remains a primary treatment, highlighting the need for improved diagnostic and surgical tools.

Purpose of the Study:

  • To characterize human seedling fibroids using optical coherence tomography (OCT).
  • To identify OCT-based features that differentiate fibroid tissue from normal uterine tissue.
  • To assess OCT's potential for improving the diagnosis and surgical planning of uterine fibroids.

Main Methods:

  • Human seedling fibroid and normal uterine tissue specimens were analyzed using optical coherence tomography (OCT).
  • OCT data were processed to extract texture, statistical, and frequency-based features.
  • Collagen fiber architecture was quantified from OCT images.

Main Results:

  • Significant differences were observed between fibroid and normal tissues in OCT-derived texture, statistical, and frequency features.
  • Collagen fiber architecture quantification revealed distinct patterns in fibroid specimens.
  • OCT demonstrated micron-resolution and near-real-time imaging capabilities.

Conclusions:

  • OCT can effectively differentiate seedling uterine fibroids from normal tissue based on microstructural characteristics.
  • OCT imaging shows promise for enhancing the early diagnosis and surgical planning of uterine fibroids.
  • Further research utilizing OCT may lead to less invasive management strategies for uterine fibroids.