Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seedling fibroid characterization using optical coherence tomography.

Biomedical optics express·2026
Same author

Side-viewing probe for lesion depth mapping on the left ventricle epicardium with near-infrared spectroscopy.

Scientific reports·2026
Same author

Three-dimensional visualization of arrhythmogenic substrate in mouse hearts using panoramic optical mapping and micro-computed tomography.

Nature cardiovascular research·2026
Same author

Double potential gradient analysis for critical isthmus detection in scar-related atrial tachycardia.

Heart rhythm·2026
Same author

Automated analysis of electrogram characteristics in baseline rhythm can distinguish isthmus regions and segments in reentrant ventricular tachycardia.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Activation signature valleys are predictive of macroreentrant atrial tachycardia bottlenecks where uniform low voltage and uniform slow conduction reside.

Heart rhythm·2026

Related Experiment Video

Updated: Jun 25, 2026

Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform
06:25

Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform

Published on: February 13, 2014

Compressed-sensing enabled forward-viewing M-mode OCT for large field of view imaging.

Aidan M Therien, Jonah A Majumder, Manuel J Jerome

    Optics Express
    |February 20, 2026
    PubMed
    Summary

    This study introduces a novel optical coherence tomography (OCT) method using compressed sensing for high-resolution 3D imaging. The technique enables clear visualization of pulmonary veins for guiding cardiac ablation procedures.

    More Related Videos

    Single Molecule Fluorescence Microscopy on Planar Supported Bilayers
    20:00

    Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

    Published on: October 31, 2015

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
    12:22

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

    Published on: August 4, 2018

    Related Experiment Videos

    Last Updated: Jun 25, 2026

    Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform
    06:25

    Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform

    Published on: February 13, 2014

    Single Molecule Fluorescence Microscopy on Planar Supported Bilayers
    20:00

    Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

    Published on: October 31, 2015

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
    12:22

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

    Published on: August 4, 2018

    Area of Science:

    • Medical Imaging
    • Biomedical Engineering
    • Cardiovascular Interventions

    Background:

    • Accurate visualization of cardiac structures is crucial for guiding minimally invasive procedures like radio-frequency ablation.
    • Existing optical coherence tomography (OCT) methods face limitations in field of view and data acquisition speed for complex 3D reconstructions.

    Purpose of the Study:

    • To develop and validate a novel 3D OCT imaging method for enhanced visualization of cardiac anatomy.
    • To improve the speed and resolution of OCT imaging for guiding catheter-based interventions.

    Main Methods:

    • Integration of a forward-viewing M-mode OCT probe with electromagnetic tracking.
    • Application of a compressed-sensing iterative soft-thresholding algorithm (CS-ISTA) for 3D image reconstruction.
    • Utilizing an 88% compression rate relative to Nyquist sampling.

    Main Results:

    • Successful 3D reconstruction of undersampled OCT volumes with high accuracy.
    • Generation of high-contrast tissue attenuation maps distinguishing pulmonary veins from atrial tissue within blood.
    • Demonstrated feasibility in phantom and ex-vivo porcine studies.

    Conclusions:

    • The developed OCT method provides the speed and image quality necessary for real-time guidance of radio-frequency ablation.
    • This technology has the potential to enhance the safety and efficacy of catheter-based cardiac interventions.
    • Compressed sensing significantly improves data acquisition efficiency in 3D OCT imaging.