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Related Experiment Video

Updated: May 31, 2026

Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

Published on: April 29, 2016

Label retaining cells and cutaneous stem cells.

Vasily V Terskikh¹, Andrey V Vasiliev, Ekaterina A Vorotelyak

¹Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.

Stem Cell Reviews and Reports

|July 12, 2011

Summary

This summary is machine-generated.

Label retaining cells (LRC) are crucial for identifying epidermal stem cells and understanding tissue regeneration. These dormant cells play a vital role in maintaining skin homeostasis and can be key to discovering stem cell niches.

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Area of Science:

Cutaneous biology
Stem cell research
Developmental biology

Background:

Identifying epidermal stem cells in vivo is critical for understanding skin biology.
Label retaining cells (LRC) are key to this identification process.
LRC research informs the broader stem cell concept.

Purpose of the Study:

Review the role of LRC in epidermal development and homeostasis.
Discuss methods for identifying and locating LRC.
Explore the proliferative potential and significance of LRC.

Main Methods:

Literature review of LRC studies in epidermal development and homeostasis.
Analysis of LRC identification and location in interfollicular epithelium and hair follicles.
Discussion of the Immortal Strand Hypothesis and its relation to LRC.

Main Results:

LRC are frequently found in stem cell niches across various tissues.
Highly dormant LRC aid in identifying stem cell niches.
LRC serve as markers for epidermal stem cells and contribute to homeostasis and regeneration.
LRC dormancy in mammals shares similarities with developmental quiescence in other organisms.

Conclusions:

LRC are essential for identifying epidermal stem cells and understanding skin homeostasis.
The study of LRC advances the stem cell concept and aids in discovering stem cell niches.
LRC dormancy provides insights into tissue regeneration and comparative biology.