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5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination

P C Clasen1, T T Wells, V S Knopik

  • 1Department of Psychology, The University of Texas at Austin, Austin, TX 78712-0187, USA. clasen@mail.utexas.edu

Genes, Brain, and Behavior
|July 13, 2011
PubMed
Summary

Genetic variations in serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF Val66Met) influence rumination. Individuals with specific gene alleles ruminate more when experiencing life stress, indicating genetic sensitivity to stress.

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