[The effect of guanosyl-5'-monophosphate on metabolic processes in rats with experimental myocarditis]

Ten days course of 5'-GMP intramuscular administration at a dose of 25 mg/kg into rats with adrenaline-produced myocarditis led to normalization of NAD content in myocardial tissue which contributed to restoration of NAD-dependent isocitrate dehydrogenase activity. During the 5'-GMP administration content of ATP and creatine phosphate was kept at the same low level as compared with controls, while restoration of glycogen content was retarded in the heart muscle. Activity of lactate dehydrogenase and lactic acid content were not altered. The decrease in content of pyruvic acid detected in response to 5'-GMP administration may occur due to elevated decarboxylation of pyruvate as a result of NAD content increase in heart muscle.